p16-Rb & p53 Pathway Interactive Simulator
Adjust the regulatory components to see their effects on cell cycle control, DNA damage response, and cancer development
Regulatory Controls
Low (0)
50%
High (100)
Normal expression
Low (0)
50%
High (100)
Normal levels
Inactive (0)
30%
Active (100)
None (0)
0%
Severe (100)
Preset Scenarios
Pathway Status
p16
50%
Inhibiting CDK4/6CDK4/6
15%
Effectively inhibitedRb
ACTIVE
HypophosphorylatedE2F
INACTIVE
Suppressed by Rbp53
50%
Monitoring for damagep21
INACTIVE
InactiveCurrent Interactions:
Rb Pathway:
- p16 → CDK4/6 inhibition: ACTIVE
- CDK4/6 → Rb phosphorylation: BLOCKED
- Rb → E2F inhibition: ACTIVE
p53 Pathway:
- DNA Damage → p53 activation: INACTIVE
- p53 → p21 induction: BLOCKED
- p21 → CDK inhibition: BLOCKED
Cell Cycle Control
CONTROLLED
Normal cell cycle checkpoints are functioning properly.
DNA Damage Response
NORMAL
No significant DNA damage detected. Normal cellular surveillance active.
Cancer Risk
LOW
Tumor suppressor pathways are functioning normally.
Clinical Relevance
Current pathway status represents normal cellular regulation with functional tumor suppressor mechanisms.